Title

• RNA interference-mediated gene silencing and its application to medical treatments of HIV-I infection diseases  
  Yuichiro Habu and Kousei Noguchi

    1

• The design of RNAi from HIV-1 before two decades  
  Yoichi Robertus Fujii

    17

• Second-generation anti-HIV-1 shRNAs: A paradigm of enhanced HIV gene therapeutic molecules  
  Jacob Samson Barnor

    31

• Suppression of HIV-1 replication by shRNA  
  Naoko Miyano-Kurosaki

    43

• Intracellular diced long-dsRNA has enhanced efficacy for silencing HCA RNA and overcome variation in viral genotype  
  Tsunamasa Watanabe and Michinori Kohara

    55

• Short hairpin RNA synthesized by phage polymerase do not induce interferon in hepatitis C virus subgenomic replicons  
  Hiroyuki Hamazaki, Saneyuki Ujino and Hiroshi Takaku

    69

• RNAi and SARS  
  Norio Yamamoto and Naoki Yamamoto

    79

• Approaches for RNAi therapeutics against cancer  
  Fumitaka Takeshita and Takahiro Ochiya

    101

• Antitumor activity of small interfering RNA (siRNA) against Bcl-2 in mouse models of cancer  
  Kazuko Hirabayashi and Junichi Yano

    117

• RNAi targeting fusion mRNAs of leukemia  
  Tomoko Kozu, Eri Sakota and Yoichiro Tanaka

    125

• siRNA-based gene therapy for autosomal dominant disease of the nervous system  
  Takanori Yokota

    137