Title

• Protein kinase inhibitors for the treatment of inflammation  An overview  
  Khusru Asadullah and Matthias Gaestel

    1

• Structural aspects of drugability and selectivity of protein kinases in inflammation  
  M. Schäfer and U. Egner

    7

• Kinases as drug targets in inflammation: In vitro and in vivo target validation and expression profiling  
  Tatjana Gust and Arne v. Bonin

    31

• In vivo target validation: Methodology and case studies on the Janus kinase Tyk2  
  Christian Gausterer, Mathias Müller and Birgit Strobl

    51

• Tyrosine kinases as targets for anti-inflammatory therapy  
  Teruko Tamura and Alexandra Koch

    87

• The role of Tec family kinases in inflammatory processes  
  Martin Melcher, Julia Raberger, Uwe Schmidt, Bernd Unger and Wilfried Ellmeier

    115

• The ERK and p38MAPK pathways as targets for anti-inflammatory therapy  
  Edward Hitti and Alexey Kotlyarov

    135