Clinical relevance of Multi Drug Resistance in chemotherapic treatment Amalia Azzariti, Letizia Porcelli and Angelo Paradiso
1
Pharmacogenomic characterization of ABC transporters involved in multidrug resistance Anh-Nhan Pham, Sravan Penchala, Robert A. Graf, Jeffrey Wang and Ying Huang
19
Drugs modulating MDR Pepita Giménez-Bonafé, Antonia Guillén Canovas, Santiago Ambrosio, Avelina Tortosa and Ricardo Pérez-Tomás
63
Overcoming multidrug resistance: Alternative approaches to P-glycoprotein modulators Stefania Nobili and Enrico Mini
101
Multidrug resistance (MDR) modulators: Verapamil offsprings and heterocyclic derivatives Elisabetta Teodori, Silvia Dei, Cecilia Martelli, Serena Scapecchi and Fulvio Gualtieri
141
Flavonoids as MDR modulating agents: SAR studies Nicola Antonio Colabufo, Francesco Berardi, Marialessandra Contino, Carmela Inglese and Roberto Perrone
171
Small molecules and acridone derivatives as P-gp inhibitors Nicola Antonio Colabufo, Francesco Berardi, Maria Grazia Perrone, Mariangela Cantore, Mauro Niso and Roberto Perrone
203
Modification of chemotherapeutic drugs to obtain potential MDR modulating agents: SAR studies Tracy A. Brooks
223
Inhibitors of P-glycoprotein-Hit identification and lead optimization Gerhard F. Ecker
243
Functional assays for identification of compounds that interact with P-gp Frances J. Sharom and Alena Siarheyeva
261
Radiolabelled probes for imaging multidrug resistance using single photon emission tomography (SPECT) and positron emission tomography (PET) Katharina J. Guenther, Trevor W. Hambley and Michael Kassiou
291
Clinical trials on MDR reversal agents Kirsty McHugh and Richard Callaghan
321
Conclusions and perspectives Roberto Perrone and Francesco Berardi
355
