Title

• The yeast chronological lifespan to study aging and diseases  
  Mario G. Mirisola and Valter D. Longo

    1

• Actin, apoptosis, and human disease - new insights from yeast  
  Vassilios N. Kotiadis, Jane E. Leadsham and Campbell W. Gourlay

    15

• Cofactor insertion into mitochondrial cytochrome c oxidase and human disease-insight from yeast models  
  Darryl Horn, Flavia Fontanesi and Antoni Barrientos

    41

• Adenine nucleotide translocase and human diseases - insights from yeast  
  Kelly Salinas and Xin Jie Chen

    63

• Dissecting the biochemical basis for Friedreich ataxia in S. cerevisiae  
  Tibor Bedekovics and Grazia Isaya

    81

• Studying homologous and heterologous prions in yeast  
  Lyne Jossé and Mick F Tuite

    97

• Unraveling the molecular basis of Parkinsonism using yeast models  
  Tiago Outeiro and Aaron Gitler

    119

• Targeting the Parkinson’s disease-related protein alpha-synuclein to the vacuole / lysosome - insights from yeast  
  Stephan N. Witt

    129

• Using yeast to study protein-protein interactions relevant to disease  
  Emily J. Bek and Marc R. Wilkins

    145

• Functional genomics approaches for identifying and characterizing genome integrity pathways in yeast  
  Marta B. Davidson and Grant W. Brown

    177

• Single-molecule analysis of DNA replication programs in yeast and mammalian cells  
  Constance Alabert, Ana María Poveda Galbaldón and Philippe Pasero

    199

• Effects of increased ploidy on the physiology of eukaryotic cells - new insights for cancer research  
  Zuzana Storchova

    223

• Pathways for suppressing and promoting gross chromosomal rearrangements in Saccharomyces cerevisiae  
  Stephanie Smith, Nilabja Sikdar, Hung-jiun Liaw Kyoo-young Lee and Kyungjae Myung

    249