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Recent advances in the biology of secretases, key proteases in Alzheimer's disease 

Editor: Wataru Araki

 

 

Beta-Secretase as a prime therapeutic target for Alzheimer's disease: a perspective from mouse model studies
Masuo Ohno

Transcriptional regulation of b-secretase expression
Hyun Jin Cho, Seok Min Jin, Inhee Mook-Jung

Regulation mechanisms of b-secretase activity
Wataru Araki

Post-translational modifications and cellular targeting of b-secretase
Richard B. Parsons, Brian M. Austen

The molecular mechanism of g-secretase-mediated intramembrane processing of APP
Xuemin Xu

Presenilin complex: core components and modulators
Hiroshi Hasegawa, Masaki Nishimura

Secretases and inflammation
Magdalena Sastre, Jochen Walter

Testing secretase inhibitors on in vivo models
Gaku Sakaguchi, Paul S. Aisen, Yasuji Matsuoka

a-Secretase and Alzheimer’s disease
Edward T. Parkin

Processing of the APP family of proteins
Kerstin Iverfeldt, Linda Adlerz

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2008
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