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Multi-drug resistance: Biological and pharmaceutical advances in antitumour treatment

Editor: Nicola Antonio Colabufo

 

 

Clinical relevance of Multi Drug Resistance in chemotherapic treatment
A. Paradiso et al.

Pharmacogenomic characterization of ABC transporters involved in multi drug resistance.
Y. Huang et al.

Pharmacological strategies to overcome Multi Drug Resistance
a. Drugs modulating MDR
R. Perez-Tomas et al.
b. Alternative approaches to overcome MDR
E. Mini et al.

MDR modulating agents: SAR studies
a. Verapamil and calmoduline antagonist analogues as MDR modulating agents: SAR studies
E. Teodori et al.
b. Natural compounds as MDR modulating agents: SAR studies
N. A. Colabufo et al.
c. Small molecules as P-gp inhibitors: SAR studies
N. A. Colabufo et al.
d. Modification of chemotherapeutic drugs to obtain potential MDR modulating agents: SAR studies
T. A. Brooks et al.
e. Inhibitors of P-glycoprotein: lead identification and optimization
G. Ecker et al.

Functional assays for identification of potential P-gp substrates and inhibitors
F. Sharom et al.

Radiolabelled Probes for Imaging MDR using PET and SPECT
M. Kassiou et al.    

Clinical Trials on MDR reversal agents
R. Callaghan et al.

Conclusions
R. Perrone and F. Berardi

 

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